Foliumzuur of folaat?

Nadine Achtereekte en Margot van Dijk
Gepubliceerd op 14 januari 2022
Laatste update juni 2025 door Nil Schubert & Margot van Dijk

In Nederland krijgen zwangeren of vrouwen die zwanger willen worden, standaard het advies om foliumzuur te slikken. Maar wat is foliumzuur eigenlijk? En wat is dan folaat? Waar is het voor nodig? En klopt het dat er een verband is met het slikken van foliumzuur en een korte tongriem bij de baby? Deze en andere vragen worden in dit artikel beantwoord.

Azzini, E., Ruggeri, S., & Polito, A. (2020). Homocysteine: Its Possible Emerging Role in At-Risk Population Groups. International Journal of Molecular Sciences, 21(4), 1421. https://doi.org/10.3390/ijms21041421
Amitai, Y., Shental, H., Atkins-Manelis, L., Koren, G., & Zamir, C. S. (2020). Pre-conceptional folic acid supplementation: A possible cause for the increasing rates of ankyloglossia. Medical Hypotheses, 134, 1–12. https://doi.org/10.1016/j.mehy.2019.109508
Becker, S., Brizuela, M., & Mendez, M. D. (2025). Ankyloglossia (Tongue-Tie).
Bergen, N., Jaddoe, V., Timmermans, S., Hofman, A., Lindemans, J., Russcher, H., Raat, H., Steegers-Theunissen, R., & Steegers, E. (2012). Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study. BJOG: An International Journal of Obstetrics & Gynaecology, 119(6), 739-751. https://doi.org/10.1111/j.1471-0528.2012.03321.x
Botto, L. D., Moore, C. A., Khoury, M. J., & Erickson, J. D. (1999). Neural-Tube Defects. New England Journal of Medicine, 341(20), 1509-1519. https://doi.org/10.1056/nejm199911113412006
Braybrook, C., Doudney, K., Marçano, A. C. B., Arnason, A., Bjornsson, A., Patton, M. A., Goodfellow, P. J., Moore, G. E., & Stanier, P. (2001). The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia. Nature Genetics, 29(2), 179–183. https://doi.org/10.1038/ng730
Cole, B. F., Baron, J. A., Sandler, R. S., Haile, R. W., Ahnen, D. J., Bresalier, R. S., McKeown-Eyssen, G., Summers, R. W., Rothstein, R. I., Burke, C. A., Snover, D. C., Church, T. R., Allen, J. I., Robertson, D. J., Beck, G. J., Bond, J. H., Byers, T., Mandel, J. S., Mott, L. A., Pearson, L. H., … Polyp Prevention Study Group (2007). Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA, 297(21), 2351-2359. https://doi.org/10.1001/jama.297.21.2351
Czeizel, A. E., & Dudás, I. (1992). Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation. New England Journal of Medicine, 327(26), 1832-1835. https://doi.org/10.1056/nejm199212243272602
Eichholzer, M., Tönz, O., & Zimmermann, R. (2006). Folic acid: a public-health challenge. Lancet (London, England), 367(9519), 1352-1361. https://doi.org/10.1016/S0140-6736(06)68582-6
Gezondheidsraad. (2003, februari). Voedingsnormen vitamine B6, foliumzuur en vitamine B12. https://www.gezondheidsraad.nl/binaries/gezondheidsraad/documenten/adviezen/2003/02/12/voedingsnormen-vitamine-b6-foliumzuur-en-vitamine-b12/advies-voedingsnormen-vitamine-b6-foliumzuur-en-vitamine-b12.pdf
Heijmans, B. T., Gussekloo, J., Kluft, C., Droog, S., Lagaay, A. M., Knook, D. L., Westendorp, R. G., & Slagboom, E. P. (1999). Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR). European Journal of Human Genetics : EJHG, 7(2), 197–204. https://doi.org/10.1038/sj.ejhg.5200283
Imani, M. M., Golchin, N., Safaei, M., Rezaei, F., Abbasi, H., Sadeghi, M., Lopez-Jornet, P., Mozaffari, H. R., & Sharifi, R. (2020). Methylenetetrahydrofolate reductase C677T polymorphism is not associated with the risk of nonsyndromic cleft lip/palate: An updated meta-analysis. Scientific Reports, 10(1), 1531. https://doi.org/10.1038/s41598-020-58357-0
Joseph, K. S., Kinniburgh, B., Metcalfe, A., Razaz, N., Sabr, Y., & Lisonkova, S. (2016). Temporal trends in ankyloglossia and frenotomy in British Columbia, Canada, 2004-2013: a population-based study. CMAJ Open, 4(1), E33–E40. https://doi.org/10.9778/cmajo.20150063
Kesuma, Y., & Liana, P. (2025). Investigating the Association Between Maternal Folic Acid Supplementation and the Occurence of Ankyloglossia in Newborns. 1–13.
Lakkakula, B. V. K. S., Sengupta, S., Agrawal, J., Singh, S., Mendhey, P., Jangde, P., Sharma, A., Pande, P. A., Krishan, P., Shukla, P., Momin, S., Nagaraju, G. P., & Pattnaik, S. (2020). Maternal and infant MTHFR gene polymorphisms and non-syndromic oral cleft susceptibility: An updated meta-analysis. Process Biochemistry, 89, 81–88. https://doi.org/https://doi.org/10.1016/j.procbio.2019.10.010
Lareb. (2021). Vitamines tijdens de zwangerschap. Geraadpleegd op 16 januari 2022, van https://www.lareb.nl/mvm-kennis-pagina?id=355&pagina=1&zoekterm=B03BB01&zwangerschap=true&borstvoeding=false&naam=Vitamines%20tijdens%20de%20zwangerschap
Martin, J. A., & Park, M. M. (1999). Trends in twin and triplet births: 1980-97. National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System, 47(24), 1-16.
Messner, A. H., Walsh, J., Rosenfeld, R. M., Schwartz, S. R., Ishman, S. L., Baldassari, C., Brietzke, S. E., Darrow, D. H., Goldstein, N., Levi, J., Meyer, A. K., Parikh, S., Simons, J. P., Wohl, D. L., Lambie, E., & Satterfield, L. (2020). Clinical Consensus Statement: Ankyloglossia in Children. Otolaryngology - Head and Neck Surgery (United States), 162(5), 597–611. https://doi.org/10.1177/0194599820915457
Mills, N., Keough, N., Geddes, D. T., Pransky, S. M., & Mirjalili, S. A. (2019). Defining the anatomy of the neonatal lingual frenulum. Clinical Anatomy, 32(6), 824–835. https://doi.org/10.1002/ca.23410
Mills, N., Pransky, S. M., Geddes, D. T., & Mirjalili, S. A. (2019). What is a tongue tie? Defining the anatomy of the in-situ lingual frenulum. Clinical Anatomy, 32(6), 749–761. https://doi.org/10.1002/ca.23343
Mitchell, L. E., Adzick, N. S., Melchionne, J., Pasquariello, P. S., Sutton, L. N., & Whitehead, A. S. (2004). Spina bifida. Lancet (London, England), 364(9448), 1885-1895. https://doi.org/10.1016/S0140-6736(04)17445-X MRC Vitamin Study Research Group. (1991). Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study. The Lancet, 338(8760), 131-137. https://doi.org/10.1016/0140-6736(91)90133-a
Natura Foundation. (2021). Folaat (Foliumzuur). https://www.naturafoundation.nl/kenniscentrum/monografie/211/folaat
Nederlands Huisartsen Genootschap. (2011). Preconceptiezorg. NHG-Richtlijnen. https://richtlijnen.nhg.org/standaarden/preconceptiezorg#volledige-tekst
Nederlands Tijdschrift voor Geneeskunde. (1993). Foliumzuur voor alle fertiele vrouwen. https://www.ntvg.nl/artikelen/foliumzuur-voor-alle-fertiele-vrouwen
Nichols, L. (2021, 22 september). Folate: Why it's Superior to Folic Acid for Pregnancy (even if you don't have MTHFR). Lily Nichols RDN.
Onderzoek Folaat 5-MTHF. (z.d.). VitamineB12Tekort.nl. Geraadpleegd op 27 september 2021, van https://vitamineb12tekort.nl/vitamineb12-tekort-folaat-5mthf.php
Prins, M., Van Roosmalen, J., Scherjon, S., & Van Roosmalen, J. (2009). Praktische verloskunde. Bohn Stafleu van Loghum.
Rijksinstituut voor Volksgezondheid en Milieu. (2019). Foliumzuur rondom de zwangerschap, gegevens in Nederland vanaf 2008. https://doi.org/10.21945/RIVM-2019-0203
Rubin, G., Stewart, C., McGowan, L., Woodside, J. V., Barrett, G., Godfrey, K. M., & Hall, J. (2023). Maternal folic acid supplementation and the risk of ankyloglossia (tongue-tie) in infants; a systematic review. PLoS ONE, 18(11 November), 1–8. https://doi.org/10.1371/journal.pone.0294042
Scaglione, F., & Panzavolta, G. (2014). Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica; the fate of foreign compounds in biological systems, 44(5), 480-488. https://doi.org/10.3109/00498254.2013.845705 Stichting Ortho Health Foundation. (2021, 30 augustus). Foliumzuur (B11), folaat en 5-MTHF: wat zijn de verschillen? SOHF. https://www.sohf.nl/blog/foliumzuur-b11-folaat-en-5-mthf-wat-zijn-de-verschillen
Tafuri, L., J Servy, E., & J R Menezo, Y. (2018). The hazards of excessive folic acid intake in MTHFR gene mutation carriers: An obstetric and gynecological perspective. Clinical Obstetrics, Gynecology and Reproductive Medicine, 4(2). https://doi.org/10.15761/cogrm.1000215
Vidmar Golja, M., ŠMid, A., Karas Kuželički, N., Trontelj, J., Geršak, K., & Mlinarič-Raščan, I. (2020). Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate. Journal of Clinical Medicine, 9(9), 2836. https://doi.org/10.3390/jcm9092836
Walsh, J., & Tunkel, D. (2017). Diagnosis and treatment of ankyloglossia in newborns and infants: A review. JAMA Otolaryngology - Head and Neck Surgery, 143(10), 1032–1039. https://doi.org/10.1001/jamaoto.2017.0948
Werler, M. M., Cragan, J. D., Wasserman, C. R., Shaw, G. M., Erickson, J. D., & Mitchell, A. A. (1997). Multivitamin supplementation and multiple births. American journal of medical genetics, 71(1), 93-96.
Widmaier, E. P., Raff, H., & Strang, K. T. (2018). Vander's Human Physiology. McGraw-Hill Education. Zaganjor, I., Sekkarie, A., Tsang, B. L., Williams, J., Razzaghi, H., Mulinare, J., Sniezek, J. E., Cannon, M. J., & Rosenthal, J. (2016). Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review. PLOS ONE, 11(4), e0151586. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151586
Zorginstituut Nederland. (2021, 3 augustus). Foliumzuur. Farmacotherapeutisch kompas. https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/f/foliumzuur